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Oncogenic T‐antigen of JC virus is present frequently in human gastric cancers

22 Jun 2006

Abstract excerpt

BACKGROUND: JC virus (JCV) is a polyomavirus that commonly infects humans and is the causative agent of progressive multifocal leukoencephalopathy in immune-compromised patients. An association between JCV and human cancers long has been suspected, because this virus induces brain tumors in several animal models. The oncogenic potential of JCV is mediated by a transforming protein, the T-antigen (T-Ag), which is...

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PMID: 16795066
DOI: 10.1002/cncr.22028

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