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Article

HIV-1 subtype influences susceptibility and response to monotherapy with the protease inhibitor lopinavir/ritonavir.

The Journal of antimicrobial chemotherapy - 1 Jan 2015

Sutherland K A, Ghosn J, Gregson J, Mbisa J L, Chaix M L, Cohen Codar I, Delfraissy J F, Delaugerre C, Gupta R K

Abstract excerpt

OBJECTIVE: PI susceptibility results from a complex interplay between protease and Gag proteins, with Gag showing wide variation across HIV-1 subtypes. We explored the impact of pre-treatment susceptibility on the outcome of lopinavir/ritonavir monotherapy. METHODS: Treatment-naive individuals who experienced lopinavir/ritonavir monotherapy failure from the MONARK study were matched (by subtype, viral load and...

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Topics

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Share to gag Gene Products, Human Immunodeficiency Virus
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Ritonavir

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Source

Open in PubMed Open full text

Identifiers

PMID: 25228587
DOI: 10.1093/jac/dku365
PMCID: PMC4267506

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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