Article
Cell-Free DNA Analysis for Trisomy Risk Assessment in First-Trimester Twin Pregnancies
15 Nov 2013
Abstract excerpt
OBJECTIVE: To examine the clinical implementation of chromosome-selective sequencing of cell-free DNA (cfDNA) in maternal blood and an algorithm that relies on the lower fetal fraction contribution of the 2 fetuses in the assessment of risk for trisomies in twin pregnancies. METHODS: Risk for trisomies 21, 18 and 13 by cfDNA testing were estimated in stored plasma samples obtained at 11-13 weeks' gestation from...
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