Article
Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers.
Journal of experimental & clinical cancer research : CR - 17 Sept 2014
Tesauro Cinzia, Graziani Grazia, Arnò Barbara, Zuccaro Laura, Muzi Alessia, D'Annessa Ilda, Santori Elettra, Tentori Lucio, Leonetti Carlo, Fiorani Paola, Desideri Alessandro
Abstract excerpt
BACKGROUND: DNA topoisomerases are key enzymes that modulate the topological state of DNA through the breaking and rejoining of DNA strands. Human topoisomerase I belongs to the family of poly(ADP-ribose)-binding proteins and is the target of camptothecin derived anticancer drugs. Poly(ADP-ribosy...
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