The A/A genotype of an interleukin-17A polymorphism predisposes to increased severity of atopic dermatitis and coexistence with asthma.

doi:10.1111/ced.12438

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Article

The A/A genotype of an interleukin-17A polymorphism predisposes to increased severity of atopic dermatitis and coexistence with asthma.

Clinical and experimental dermatology - 1 Jan 2015

Narbutt J, Wojtczak M, Zalińska A, Salinski A, Przybylowska-Sygut K, Kuna P, Majak P, Sysa-Jedrzejowska A, Lesiak A

Abstract excerpt

INTRODUCTION: Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM: To investigate the asso...

Topics

Adolescent
Adult
Alleles
Asthma
Case-Control Studies
Child
Child, Preschool
Dermatitis, Atopic
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Incidence
Infant
Interleukin-17
Male
Poland

Source

Open in PubMed

Identifiers

PMID: 25223230
DOI: 10.1111/ced.12438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25223230-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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