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Article

Epigenetic modifications of splicing factor genes in myelodysplastic syndromes and acute myeloid leukemia.

Cancer science - 1 Nov 2014

Wong Justin J-L, Lau Katherine A, Pinello Natalia, Rasko John E J

Abstract excerpt

Somatic mutations in splicing factor genes have frequently been reported in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Although aberrant epigenetic changes are frequently implicated in blood cancers, their direct role in suppressing one or both alleles of critical splicing...

Read the complete abstract on PubMed

Topics

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Share to Epigenesis, Genetic
Share to Gene Expression Regulation, Leukemic
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Ribonucleoproteins

Share to RNA Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 25220401
DOI: 10.1111/cas.12532
PMCID: PMC4462368

Genes

YBX3
ZRSR2
HNRNPR
MATR3
SRSF2
ZFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25220401-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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