Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013.

doi:10.1128/JVI.01887-14

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013.

Journal of virology - 1 Dec 2014

Rith Sareth, Davis C Todd, Duong Veasna, Sar Borann, Horm Srey Viseth, Chin Savuth, Ly Sovann, Laurent Denis, Richner Beat, Oboho Ikwo, Jang Yunho, Davis William, Thor Sharmi, Balish Amanda, Iuliano A Danielle, Sorn San, Holl Davun, Sok Touch, Seng Heng, Tarantola Arnaud, Tsuyuoka Reiko, Parry Amy, Chea Nora, Allal Lotfi, Kitsutani Paul, Warren Dora, Prouty Michael, Horwood Paul, Widdowson Marc-Alain, Lindstrom Stephen, Villanueva Julie, Donis Ruben, Cox Nancy, Buchy Philippe

Abstract excerpt

Human infections with influenza A(H5N1) virus in Cambodia increased sharply during 2013. Molecular characterization of viruses detected in clinical specimens from human cases revealed the presence of mutations associated with the alteration of receptor-binding specificity (K189R, Q222L) and respiratory droplet transmission in ferrets (N220K with Q222L). Discovery of quasispecies at position 222 (Q/L), in addition...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cambodia

Share to Cluster Analysis

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H5N1 Subtype

Share to Influenza, Human

Share to Mutation, Missense

Share to Virus Attachment

Source

Open in PubMed Open full text

Identifiers

PMID: 25210193
DOI: 10.1128/JVI.01887-14
PMCID: PMC4248976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of molecular markers associated with alteration of receptor-binding specificity in a novel genotype of highly pathogenic avian influenza A(H5N1) viruses detected in Cambodia in 2013.PMID 25210193Read ↗

The evolution and genetic diversity of avian influenza A(H9N2) viruses in Cambodia, 2015 - 2016.Semantic proximity Read ↗

Inventory of molecular markers affecting biological characteristics of avian influenza A virusesSemantic proximity Read ↗

Variation and Molecular Basis for Enhancement of Receptor Binding of H9N2 Avian Influenza Viruses in China IsolatesSemantic proximity Read ↗

The H4 subtype of avian influenza virus: a review of its historical evolution, global distribution, adaptive mutations and receptor binding properties.Semantic proximity Read ↗

Molecular characterization and receptor binding specificity of H9N2 avian influenza viruses based on poultry-related environmental surveillance in China between 2013 and 2016Semantic proximity Read ↗

Epidemiological and Virological Characteristics of Influenza Viruses Circulating in Cambodia from 2009 to 2011Semantic proximity Read ↗

Dual receptor-binding, infectivity, and transmissibility of an emerging H2N2 low pathogenicity avian influenza virus.Semantic proximity Read ↗

Diversity of A(H5N1) clade 2.3.2.1c avian influenza viruses with evidence of reassortment in Cambodia, 2014-2016.Semantic proximity Read ↗

Genetics, receptor binding property, and transmissibility in mammals of naturally isolated H9N2 Avian Influenza viruses.Semantic proximity Read ↗

Genetics, Receptor Binding, and Virulence in Mice of H10N8 Influenza Viruses Isolated from Ducks and Chickens in Live Poultry Markets in China.Semantic proximity Read ↗

Receptor binding and transmission studies of H5N1 influenza virus in mammalsSemantic proximity Read ↗

Amino acid substitutions in low pathogenic avian influenza virus strains isolated from wild birds in Korea.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.