Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.

doi:10.1186/s40478-014-0136-4

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Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.

Acta neuropathologica communications - 11 Sept 2014

Ota Kiyobumi, Obayashi Masato, Ozaki Kokoro, Ichinose Shizuko, Kakita Akiyoshi, Tada Mari, Takahashi Hitoshi, Ando Noboru, Eishi Yoshinobu, Mizusawa Hidehiro, Ishikawa Kinya

Abstract excerpt

p25α/tubulin polymerization promoting protein (TPPP) is an oligodendroglial protein that plays crucial roles including myelination, and the stabilization of microtubules. In multiple system atrophy (MSA), TPPP is suggested to relocate from the myelin sheath to the oligodendroglial cell body, before the formation of glial cytoplasmic inclusions (GCIs), the pathologic hallmark of MSA. However, much is left unknown...

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Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy.

Abstract excerpt

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