Article
Elevated levels of the neutrophil chemoattractant pro-platelet basic protein in macrophages from individuals with chronic and allergic aspergillosis.
The Journal of infectious diseases - 15 Feb 2015
Smith Nicola L D, Bromley Michael J, Denning David W, Simpson Angela, Bowyer Paul
Abstract excerpt
BACKGROUND: Aspergillus fumigatus causes chronic cavitary pulmonary aspergillosis (CCPA) and allergic bronchopulmonary aspergillosis (ABPA) in overtly immunocompetent and atopic individuals, respectively. Disease mechanisms are poorly understood but may be related to increased neutrophil presence and activation. Pro-platelet basic protein (PPBP) is a potent neutrophil chemoattractant and activator whose...
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