Article
Whole-genome sequencing of asian lung cancers: second-hand smoke unlikely to be responsible for higher incidence of lung cancer among Asian never-smokers.
Cancer research - 1 Nov 2014
Krishnan Vidhya G, Ebert Philip J, Ting Jason C, Lim Elaine, Wong Swee-Seong, Teo Audrey S M, Yue Yong G, Chua Hui-Hoon, Ma Xiwen, Loh Gary S L, Lin Yuhao, Tan Joanna H J, Yu Kun, Zhang Shenli, Reinhard Christoph, Tan Daniel S W, Peters Brock A, Lincoln Stephen E, Ballinger Dennis G, Laramie Jason M, Nilsen Geoffrey B, Barber Thomas D, Tan Patrick, Hillmer Axel M, Ng Pauline C
Abstract excerpt
Asian nonsmoking populations have a higher incidence of lung cancer compared with their European counterparts. There is a long-standing hypothesis that the increase of lung cancer in Asian never-smokers is due to environmental factors such as second-hand smoke. We analyzed whole-genome sequencing of 30 Asian lung cancers. Unsupervised clustering of mutational signatures separated the patients into two categories...
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