Article
Mutual effect of rs688 and rs5925 in regulating low-density lipoprotein receptor splicing.
DNA and cell biology - 1 Dec 2014
Lee Jiann-Der, Hsiao Kuang-Ming, Wang Ting-Chung, Lee Tsong-Hai, Kuo Ya-Wen, Huang Yen-Chu, Hsu Huan-Lin, Lin Ya-Hui, Wu Chih-Ying, Huang Ying-Chih, Lee Meng, Yang Hsin-Ta, Hsu Chia-Yu, Pan Yi-Ting
Abstract excerpt
Analysis of the low-density lipoprotein receptor (LDLR) gene based on the rs688 and rs5925 genetic polymorphisms has provided evidence suggesting that haplotypes related to rs688 and rs5925 are associated with ischemic cerebrovascular diseases. Both rs688 and rs5925 have been empirically identified as exon-splicing enhancers in silico, and has been shown to be a functional polymorphism that modulates LDLR...