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Article

Lineage Tracing of Stem and Progenitor Cells of the Murine Corneal Epithelium

3 Sept 2014

Abstract excerpt

Accumulating evidence supports the dogma that the corneal epithelium is regenerated by stem cells located exclusively in the limbal niche, at the corneal periphery. Accordingly, limbal stem cells (LSCs) give rise to progenitors that proliferate and migrate centripetally to repopulate the corneal epithelium, which has a short turnover. Moreover, LSC loss leads to corneal opacity and blindness, while limbal...

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PMID: 25187087
DOI: 10.1002/stem.1840

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Single-cell transcriptomics identifies limbal stem cell population and cell types mapping its differentiation trajectory in limbal basal epithelium of human corneaSemantic proximity Read ↗

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