Article
Two novel mutations of pfdhps K540T and I588F, affecting sulphadoxine-pyrimethamine-resistant response in uncomplicated falciparum malaria at Banjar district, South Kalimantan Province, Indonesia.
Malaria journal - 4 Apr 2014
Basuki Sukmawati, Fitriah, Riyanto Sugeng, Budiono, Dachlan Yoes P, Uemura Haruki
Abstract excerpt
BACKGROUND: Mutations in pfdhfr and pfdhps genes have been shown to associate with sulphadoxine-pyrimethamine (SP) resistance of Plasmodium falciparum parasites. However, pfdhfr, pfdhps genotypes and the correlations to SP treatment outcome in Indonesia has not yet been well analysed. METHODS: After obtaining informed consent, 61 uncomplicated falciparum malaria patients were recruited in Banjar district, South...
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