Article
New insights about miRNAs in cystic fibrosis.
The American journal of pathology - 1 Apr 2015
Sonneville Florence, Ruffin Manon, Guillot Loïc, Rousselet Nathalie, Le Rouzic Philippe, Corvol Harriet, Tabary Olivier
Abstract excerpt
The molecular basis of cystic fibrosis (CF) is a mutation-related defect in the epithelial-cell chloride channel called CF transmembrane conductance regulator (CFTR). This defect alters chloride ion transport and impairs water transport across the cell membrane. Marked clinical heterogeneity occurs even among patients carrying the same mutation in the CFTR gene. Recent studies suggest that such heterogeneity...
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