Article
A novel system for predicting the toxicity of irinotecan based on statistical pattern recognition with UGT1A genotypes.
International journal of oncology - 1 Oct 2014
Tsunedomi Ryouichi, Hazama Shoichi, Fujita Yusuke, Okayama Naoko, Kanekiyo Shinsuke, Inoue Yuka, Yoshino Shigefumi, Yamasaki Takahiro, Suehiro Yutaka, Oba Koji, Mishima Hideyuki, Sakamoto Junichi, Hamamoto Yoshihiko, Oka Masaaki
Abstract excerpt
To predict precisely severe toxicity of irinotecan, we evaluated the association of UGT1A variants, haplotypes and the combination of UGT1A genotypes to severe toxicity of irinotecan. UGT1A1*6 (211G>A), UGT1A1*28 (TA6>TA7), UGT1A1*60 (-3279T>G), UGT1A7 (387T>G), UGT1A7 (622T>C), and UGT1A9*1b (-118T9>T10, also named *22) were genotyped in 123 patients with metastatic colorectal cancer who had received...
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