Article
Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer.
Medical oncology (Northwood, London, England) - 1 Oct 2014
Nicoś Marcin, Powrózek Tomasz, Krawczyk Paweł, Jarosz Bożena, Pająk Beata, Sawicki Marek, Kucharczyk Krzysztof, Trojanowski Tomasz, Milanowski Janusz
Abstract excerpt
Discoidin death receptor 2 (DDR2) receptor belongs to a DDR family that shows a tyrosine kinase activity. The somatic mutations in DDR2 gene, reported in non-small cell lung cancer (NSCLC), are involved in up-regulation of cells' migration, proliferation and survival. A S768R substitution in DDR2 gene was commonly reported in squamous cell lung carcinoma. Clinical data of patients carrying the DDR2 gene mutation...
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