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Ultrafast tissue staining with chemical tags

25 Aug 2014

Abstract excerpt

Genetically encoded fluorescent proteins and immunostaining are widely used to detect cellular and subcellular structures in fixed biological samples. However, for thick or whole-mount tissue, each approach suffers from limitations, including limited spectral flexibility and lower signal or slow speed, poor penetration, and high background labeling, respectively. We have overcome these limitations by using...

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PMID: 25157152
DOI: 10.1073/pnas.1411087111

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