Diffusion tensor imaging of patients with proteolipid protein 1 gene mutations.

Abstract excerpt

Pelizaeus-Merzbacher disease (PMD) is an X-linked disorder of the central nervous system (CNS) caused by a wide variety of mutations affecting proteolipid protein 1 (PLP1). We assessed the effects of PLP1 mutations on water diffusion in CNS white matter by using diffusion tensor imaging. Twelve patients with different PLP1 point mutations encompassing a range of clinical phenotypes were analyzed, and the results...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Brain
• Share to Corpus Callosum
• Share to Diffusion Tensor Imaging