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Article

Novel pathologic findings in patients with Pelizaeus-Merzbacher disease.

Neuroscience letters - 3 Aug 2016

Laukka Jeremy J, Kamholz John, Bessert Denise, Skoff Robert P

Abstract excerpt

Pelizaeus-Merzbacher disease (PMD) is an X-linked inherited hypomyelinating disorder caused by mutations in the gene encoding proteolipid protein (PLP), the major structural protein in central nervous system (CNS) myelin. Prior to our study, whether hypomyelination in PMD was caused by demyelination, abnormally thin sheaths or failure to form myelin was unknown. In this study, we compared the microscopic...

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Source

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Identifiers

PMID: 27222925
DOI: 10.1016/j.neulet.2016.05.028
PMCID: PMC4948744

Genes

PLP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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