Using Galaxy-P to leverage RNA-Seq for the discovery of novel protein variations.

Abstract excerpt

BACKGROUND: Current practice in mass spectrometry (MS)-based proteomics is to identify peptides by comparison of experimental mass spectra with theoretical mass spectra derived from a reference protein database; however, this strategy necessarily fails to detect peptide and protein sequences that are absent from the database. We and others have recently shown that customized proteomic databases derived from...

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