Article
Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia.
Human molecular genetics - 1 Jan 2015
Oudejans Cees B M, Michel Omar J, Janssen Rob, Habets Rob, Poutsma Ankie, Sistermans Erik A, Weiss Marjan M, Incarnato Danny, Oliviero Salvatore, Kleiverda Gunilla, Van Dijk Marie, Arngrímsson Reynir
Abstract excerpt
In humans, the elucidation of the genetics underlying multifactorial diseases such as pre-eclampsia remains complex. Given the current day availability of genome-wide linkage- and expression data pools, we applied pathway-guided genome-wide meta-analysis guided by the premise that the functional network underlying these multifactorial syndromes is under selective genetic pressure. This approach drastically...
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