Article
The presence of clustered circulating tumor cells (CTCs) and circulating cytokines define an aggressive phenotype in metastatic colorectal cancer.
Cancer causes & control : CCC - 1 Nov 2014
Divella Rosa, Daniele Antonella, Abbate Ines, Bellizzi Antonia, Savino Eufemia, Simone Giovanni, Giannone Grazia, Giuliani Francesco, Fazio Vito, Gadaleta-Caldarola Gennaro, Gadaleta Cosimo Damiano, Lolli Ivan, Sabbà Carlo, Mazzocca Antonio
Abstract excerpt
PURPOSE: Colon carcinoma is a malignant tumor showing a marked preference to metastasize to distant organs. The presence of circulating tumor cells (CTCs) in the peripheral blood is a prerequisite for the formation of distant metastases. However, whether circulating cytokines are linked to the circulation of tumor cells, as individual cells or clusters, remain unclear. In this study, we investigated the...
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