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Article

Metabolic engineering of Saccharomyces cerevisiae for caffeine and theobromine production.

PloS one - 1 Jan 2014

Jin Lu, Bhuiya Mohammad Wadud, Li Mengmeng, Liu XiangQi, Han Jixiang, Deng WeiWei, Wang Min, Yu Oliver, Zhang Zhengzhu

Abstract excerpt

Caffeine (1, 3, 7-trimethylxanthine) and theobromine (3, 7-dimethylxanthine) are the major purine alkaloids in plants, e.g., tea (Camellia sinensis) and coffee (Coffea arabica). Caffeine is a major component of coffee and is used widely in food and beverage industries. Most of the enzymes involved in the caffeine biosynthetic pathway have been reported previously. Here, we demonstrated the biosynthesis of...

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PMID: 25133732
DOI: 10.1371/journal.pone.0105368
PMCID: PMC4136831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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