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Article

CRISPR/Cas9-mediated genome editing reveals the synergistic effects of β-defensin family members on sperm maturation in rat epididymis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2018

Zhang Chaobao, Zhou Yuchuan, Xie Shengsong, Yin Qianqian, Tang Chunhua, Ni Zimei, Fei Jian, Zhang Yonglian

Abstract excerpt

The epididymis is a male reproductive organ involved in posttesticular sperm maturation and storage, but the mechanism underlying sperm maturation remains unclear. β-Defensins (Defbs) belong to a family of small, cysteine-rich, cationic peptides that are antimicrobial and modulate the immune response. A large number of Defb genes are expressed abundantly in the male reproductive tract, especially in the...

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Identifiers

PMID: 29141997
DOI: 10.1096/fj.201700936R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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