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Article

Epigenetic Silencing of CXCR4 Promotes Loss of Cell Adhesion in Cervical Cancer

1 Jan 2014

Abstract excerpt

In the network of chemokine signaling pathways, recent reports have described the SDF-1α/CXCR4 axis and its role in cancer progression and metastasis. Interestingly, we found downregulation of CXCR4 at both transcript and protein level in cervical cancer cell lines and primary tumors. We also found CXCR4 promoter hypermethylation in cervical cancer cell lines and primary biopsy samples. DNA hypomethylating drug...

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PMID: 25114911
DOI: 10.1155/2014/581403

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