Article
Pleiotropic functions for transcription factor zscan10.
PloS one - 1 Jan 2014
Kraus Petra, V Sivakamasundari, Yu Hong Bing, Xing Xing, Lim Siew Lan, Adler Thure, Pimentel Juan Antonio Aguilar, Becker Lore, Bohla Alexander, Garrett Lillian, Hans Wolfgang, Hölter Sabine M, Janas Eva, Moreth Kristin, Prehn Cornelia, Puk Oliver, Rathkolb Birgit, Rozman Jan, Adamski Jerzy, Bekeredjian Raffi, Busch Dirk H, Graw Jochen, Klingenspor Martin, Klopstock Thomas, Neff Frauke, Ollert Markus, Stoeger Tobias, Yildrim Ali Önder, Eickelberg Oliver, Wolf Eckhard, Wurst Wolfgang, Fuchs Helmut, Gailus-Durner Valérie, de Angelis Martin Hrabě, Lufkin Thomas, Stanton Lawrence W
Abstract excerpt
The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays. Here we suggest a potential role of Zscan10 in controlling progenitor cell populations in vivo. Mice homozygous for a Zscan10 mutation exhibit reduced weight, mild hypoplasia in the spleen, heart and long bones and phenocopy an eye...
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