Article
Association of the genetic variants of luteinizing hormone, luteinizing hormone receptor and polycystic ovary syndrome.
Reproductive biology and endocrinology : RB&E - 30 Apr 2012
Liu Nana, Ma Yanmin, Wang Shuyu, Zhang Xiaowei, Zhang Qiufang, Zhang Xue, Fu Li, Qiao Jie
Abstract excerpt
BACKGROUND: High circulating luteinizing hormone (LH) level is a typical biochemical feature of polycystic ovary syndrome (PCOS) whose pathophysiology is still unclear. Certain mutations of LH and LH receptor (LHR) may lead to changes in bioactivity of these hormones. The aim of this study was determine the role of the LH and LHR polymorphisms in the pathogenesis of PCOS using a genetic approach. METHODS: 315...
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