Article
Induction of adult levels of β-globin in human erythroid cells that intrinsically express embryonic or fetal globin by transduction with KLF1 and BCL11A-XL.
Haematologica - 1 Nov 2014
Trakarnsanga Kongtana, Wilson Marieangela C, Lau Winnie, Singleton Belinda K, Parsons Steve F, Sakuntanaga Punthita, Kurita Ryo, Nakamura Yukio, Anstee David J, Frayne Jan
Abstract excerpt
A major barrier to the clinical use of erythrocytes generated in vitro from pluripotent stem cells or cord blood progenitors is failure of these erythrocytes to express adult hemoglobin. The key regulators of globin switching KLF1 and BCL11A are absent or at a lower level than in adult cells in K562 and erythroid cells differentiated in vitro from induced pluripotent stem cells and cord blood progenitors....
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