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Article

Reduction in hSOD1 copy number significantly impacts ALS phenotype presentation in G37R (line 29) mice: implications for the assessment of putative therapeutic agents.

Journal of negative results in biomedicine - 8 Aug 2014

Zwiegers Pierre, Lee Grace, Shaw Christopher A

Abstract excerpt

BACKGROUND: In vivo animal models of familial amyotrophic lateral sclerosis (fALS) are widely used to delineate the potential role that genetic mutations play in the neurodegenerative process. While these models are extensively used for establishing the safety and efficacy of putative therapeutics during pre-clinical development, effective clinical translation of pharmacological interventions has been largely...

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Source

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Identifiers

PMID: 25103619
DOI: 10.1186/1477-5751-13-14
PMCID: PMC4134475

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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