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Article

The response to high CO2 levels requires the neuropeptide secretion component HID-1 to promote pumping inhibition.

PLoS genetics - 1 Aug 2014

Sharabi Kfir, Charar Chayki, Friedman Nurit, Mizrahi Inbar, Zaslaver Alon, Sznajder Jacob I, Gruenbaum Yosef

Abstract excerpt

Carbon dioxide (CO2) is a key molecule in many biological processes; however, mechanisms by which organisms sense and respond to high CO2 levels remain largely unknown. Here we report that acute CO2 exposure leads to a rapid cessation in the contraction of the pharynx muscles in Caenorhabditis elegans. To uncover the molecular mechanisms underlying this response, we performed a forward genetic screen and found...

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Identifiers

PMID: 25101962
DOI: 10.1371/journal.pgen.1004529
PMCID: PMC4125093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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