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Article

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.

PLoS genetics - 1 Aug 2014

Chewapreecha Claire, Marttinen Pekka, Croucher Nicholas J, Salter Susannah J, Harris Simon R, Mather Alison E, Hanage William P, Goldblatt David, Nosten Francois H, Turner Claudia, Turner Paul, Bentley Stephen D, Parkhill Julian

Abstract excerpt

Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants. Beta-lactam antibiotic resistance in Streptococcus pneumoniae arises readily as the bacteria can quickly incorporate DNA fragments encompassing variants that make the transformed strains resistant. However, the...

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Identifiers

PMID: 25101644
DOI: 10.1371/journal.pgen.1004547
PMCID: PMC4125147

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