Article
HLA-C*12:02 is a susceptibility factor in late-onset type of psoriasis in Japanese.
The Journal of dermatology - 1 Aug 2014
Mabuchi Tomotaka, Ota Tami, Manabe Yasuaki, Ikoma Norihiro, Ozawa Akira, Terui Tadashi, Ikeda Shigaku, Inoko Hidetoshi, Oka Akira
Abstract excerpt
Psoriasis is thought to be a multifactorial disease triggered by both genetic and environmental factors. The HLA-C locus on chromosome 6p21.33 remains the strongest susceptibility candidate locus in psoriasis. The strong association between psoriasis and the HLA-Cw6 allele has been well documented in various races. It is known that psoriatic patients with early onset are more likely to be familial and associated...
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