Article
Different segregation patterns in five carriers due to a pericentric inversion of chromosome 1.
Systems biology in reproductive medicine - 1 Dec 2014
Luo Yuqin, Xu Chenming, Sun Yixi, Wang Liya, Chen Songchang, Jin Fan
Abstract excerpt
Pericentric inversion can produce recombinant gametes; however, meiotic segregation studies on the relationship between the frequency of recombinants and the inverted segment size are rare. Triple-color fluorescence in situ hybridization (FISH) was performed to analyze the meiotic behavior in five inv(1) carriers with different breakpoints. Recombination gametes were absent in Patient 1, whereas the percentages...
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