Article
Extreme neonatal hyperbilirubinemia and a specific genotype: a population-based case-control study.
Pediatrics - 1 Sept 2014
Petersen Jesper Padkær, Henriksen Tine Brink, Hollegaard Mads Vilhelm, Vandborg Pernille Kure, Hougaard David Michael, Thorlacius-Ussing Ole, Ebbesen Finn
Abstract excerpt
OBJECTIVES: Extreme hyperbilirubinemia (plasma bilirubin ≥ 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. Several risk factors for hyperbilirubinemia are known, but in a large number of patients, a causal factor is never established. UGT1A1 is the rate-limiting enzyme in bilirubin's metabolism. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly reduced activity...
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