Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epigenetic coordination of acute systemic inflammation: potential therapeutic targets

4 Aug 2014

Abstract excerpt

Epigenetic reprogramming of thousands of genes directs the course of acute systemic inflammation, which is highly lethal when dysregulated during sepsis. No molecular-based treatments for sepsis are available. A new concept supports that sepsis is an immunometabolic disease and that loss of control of nuclear epigenetic regulator sirtuin 1 (SIRT-1), a NAD(+) sensor directs immune and metabolic pathways during...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Medicinal Plants and Bioactive Compounds
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25088223
DOI: 10.1586/1744666x.2014.943192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epigenetic coordination of acute systemic inflammation: potential therapeutic targetsPMID 25088223Read ↗

Sirtuins and Sepsis: Cross Talk between Redox and Epigenetic PathwaysSemantic proximity Read ↗

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.Semantic proximity Read ↗

Research Progress into the Regulatory Mechanism of Silent Information Regulator 1 in SepsisSemantic proximity Read ↗

Epigenetic and metabolic programming of innate immunity in sepsisSemantic proximity Read ↗

NAD+-dependent SIRT1 Deacetylase Participates in Epigenetic Reprogramming during Endotoxin ToleranceSemantic proximity Read ↗

Epigenetic Mechanisms in Sepsis-Associated Acute Kidney InjurySemantic proximity Read ↗

The Epigenetics of Sepsis: How Gene Modulation Shapes OutcomesSemantic proximity Read ↗

NAD+ dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65.Semantic proximity Read ↗

Sepsis, immunosuppression and the role of epigenetic mechanismsSemantic proximity Read ↗

Epigenetic Biomarkers for Human Sepsis and Septic Shock: Insights from ImmunosuppressionSemantic proximity Read ↗

Epigenetic regulation of immune cell functions during post-septic immunosuppressionSemantic proximity Read ↗

Novel Insights Into the Potential Mechanisms of N6-Methyladenosine RNA Modification on Sepsis-Induced Cardiovascular Dysfunction: An Update Summary on Direct and Indirect EvidencesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.