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Article

Compact conformations of human protein disulfide isomerase.

PloS one - 1 Jan 2014

Yang Shang, Wang Xi, Cui Lei, Ding Xiang, Niu Lili, Yang Fuquan, Wang Chao, Wang Chih-Chen, Lou Jizhong

Abstract excerpt

Protein disulfide isomerase (PDI) composed of four thioredoxin-like domains a, b, b', and a', is a key enzyme catalyzing oxidative protein folding in the endoplasmic reticulum. Large scale molecular dynamics simulations starting from the crystal structures of human PDI (hPDI) in the oxidized and reduced states were performed. The results indicate that hPDI adopts more compact conformations in solution than in the...

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Identifiers

PMID: 25084354
DOI: 10.1371/journal.pone.0103472
PMCID: PMC4118876

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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