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Article

Exploring the Folding Mechanism of Dimeric Superoxide Dismutase.

The journal of physical chemistry. B - 16 Feb 2023

Mouro Paulo R, Sanches Murilo N, Leite Vitor B P, Chahine Jorge

Abstract excerpt

The Cu/Zn Human Superoxide Dismutase (SOD1) is a dimeric metalloenzyme whose genetic mutations are directly related to amyotrophic lateral sclerosis (ALS), so understanding its folding mechanism is of fundamental importance. Currently, the SOD1 dimer formation is studied via molecular dynamics simulations using a simplified structure-based model and an all-atom model. Results from the simplified model reveal a...

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PMID: 36716437
DOI: 10.1021/acs.jpcb.2c08877

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