MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis.

doi:10.3324/haematol.2013.101170

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Article

MDM2 promotor polymorphism and disease characteristics in chronic lymphocytic leukemia: results of an individual patient data-based meta-analysis.

Haematologica - 1 Aug 2014

Benner Axel, Mansouri Larry, Rossi Davide, Majid Aneela, Willander Kerstin, Parker Anton, Bond Gareth, Pavlova Sarka, Nückel Holger, Merkel Olaf, Ghia Paolo, Montserrat Emili, Kaderi Mohd Arifin, Rosenquist Richard, Gaidano Gianluca, Dyer Martin J S, Söderkvist Peter, Linderholm Mats, Oscier David, Tvaruzkova Zuzana, Pospisilova Sarka, Dührsen Ulrich, Greil Richard, Döhner Hartmut, Stilgenbauer Stephan, Zenz Thorsten

Abstract excerpt

A number of single nucleotide polymorphisms have been associated with disease predisposition in chronic lymphocytic leukemia. A single nucleotide polymorphism in the MDM2 promotor region, MDM2SNP309, was shown to soothe the p53 pathway. In the current study, we aimed to clarify the effect of the MDM2SNP309 on chronic lymphocytic leukemia characteristics and outcome. We performed a meta-analysis of data from 2598...

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PMID: 25082786
DOI: 10.3324/haematol.2013.101170
PMCID: PMC4116826

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MDM2

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