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Article

Hematopoietic clonal dominance, stem cell mutations, and evolutionary pattern of JAK2V617F allele burden in polycythemia vera.

European journal of haematology - 1 Mar 2015

Angona Anna, Alvarez-Larrán Alberto, Bellosillo Beatriz, Martínez-Avilés Luz, Camacho Laura, Fernández-Rodríguez Concepción, Pairet Silvia, Longarón Raquel, Ancochea Águeda, Senín Alicia, Florensa Lourdes, Besses Carles

Abstract excerpt

OBJECTIVES: Clonal dominance is characteristic of patients with post-polycythemia vera myelofibrosis (post-PV MF), whereas patients in chronic phase usually display polyclonal hematopoiesis. The aim of this work was to study the mutational burden of JAK2V617F at the progenitor level in patients with PV and correlate it with the evolutive phase of the disease and the presence of mutations in genes different to...

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Source

Identifiers

PMID: 25082530
DOI: 10.1111/ejh.12425

Genes

TET2
ASXL1
SRSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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