Genome-wide analysis of genetic variations assisted by Ingenuity Pathway Analysis to comprehensively investigate potential genetic targets associated with the progression of hepatocellular carcinoma.

Abstract excerpt

OBJECTIVES: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors and the third cause of cancer death worldwide. The development of HCC is a multi-pathway regulated process including a variety of genetic mutations and variations. MATERIALS AND METHODS: To get an insight into the overall genetic aberration, we analyzed the gene expression profile of 9 HCC samples and 9 normal liver tissues as...

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