Article
Novel use for an EGFR mutation-specific antibody in discriminating lung adenocarcinoma from reactive pneumocyte hyperplasia.
Histopathology - 1 May 2015
Mimori Tomoyasu, Kobayashi Saori, Tanaka Ayako, Sasada Shinji, Yoshida Akihiko, Izumo Takehiro, Sasaki Naoshi, Tsuchida Takaaki, Tsuta Koji
Abstract excerpt
AIMS: Pulmonary ground-glass nodules (GGNs) are frequently observed. Histopathologically, their presentation can indicate a wide range of disorders from an inflammatory process to malignancy. An accurate diagnosis based on GGNs can sometimes be challenging on small-sized biopsies. Mutations in the EGFR gene are detected in pulmonary adenocarcinomas (ADCs). Immunohistochemical analysis using antibodies that detect...
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