Article
Acute liver failure after valproate exposure in patients with POLG1 mutations and the prognosis after liver transplantation.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society - 1 Nov 2014
Hynynen Johanna, Komulainen Tuomas, Tukiainen Eija, Nordin Arno, Arola Johanna, Kälviäinen Reetta, Jutila Leena, Röyttä Matias, Hinttala Reetta, Majamaa Kari, Mäkisalo Heikki, Uusimaa Johanna
Abstract excerpt
Patients with mutations in the POLG1 gene encoding mitochondrial DNA polymerase gamma have an increased risk of valproate-induced liver failure. POLG1 mutations are common, and these patients often suffer from intractable seizures. The role of liver transplantation in the treatment of patients with mitochondrial diseases has been controversial. We studied valproate-induced liver failure associated with POLG1...
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