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Article

Valproic acid triggers increased mitochondrial biogenesis in POLG-deficient fibroblasts

28 Mar 2014

Abstract excerpt

Valproic acid (VPA) is a widely used antiepileptic drug and also prescribed to treat migraine, chronic headache and bipolar disorder. Although it is usually well tolerated, a severe hepatotoxic reaction has been repeatedly reported after VPA administration. A profound toxic reaction on administration of VPA has been observed in several patients carrying POLG mutations, and heterozygous genetic variation in POLG...

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Identifiers

PMID: 24725338
DOI: 10.1016/j.ymgme.2014.03.006

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