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Article

Efficacy of diflunisal on autonomic dysfunction of late-onset familial amyloid polyneuropathy (TTR Val30Met) in a Japanese endemic area.

Journal of the neurological sciences - 15 Oct 2014

Takahashi Ryoichi, Ono Kenjiro, Shibata Shutaro, Nakamura Keiko, Komatsu Junji, Ikeda Yoshihisa, Ikeda Tokuhei, Samuraki Miharu, Sakai Kenji, Iwasa Kazuo, Kayano Daiki, Yamada Masahito

Abstract excerpt

OBJECTIVE: To evaluate the long-term efficacy and safety of diflunisal in late-onset familial amyloid polyneuropathy (FAP) in a Japanese endemic area. METHODS: Consecutive six FAP patients (mean age: 65.8 ± 7.3 years) with a transthyretin (TTR) Val30Met mutation from an endemic area of late-onset FAP were prospectively recruited to an open label study with oral diflunisal (250 mg twice a day). We evaluated...

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Share to Amyloid Neuropathies, Familial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25060417
DOI: 10.1016/j.jns.2014.07.017

Genes

FAP
TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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