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Article

ACTN3 R577X polymorphism and long-term survival in patients with chronic heart failure.

BMC cardiovascular disorders - 24 Jul 2014

Bernardez-Pereira Sabrina, Santos Paulo Caleb Junior Lima, Krieger Jose Eduardo, Mansur Alfredo Jose, Pereira Alexandre Costa

Abstract excerpt

BACKGROUND: Previous studies have shown the occurrence of actinin-3 deficiency in the presence of the R577X polymorphism in the ACTN3 gene. Our hypothesis is that this deficiency, by interfering with the function of skeletal muscle fiber, can result in a worse prognosis in patients with chronic heart failure. METHODS: A prospective cohort study was conducted from 2002 to 2004. The eligibility criteria included...

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Identifiers

PMID: 25059829
DOI: 10.1186/1471-2261-14-90
PMCID: PMC4113663

Genes

ACTN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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