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Article

Clan genomics and the complex architecture of human disease.

Cell - 30 Sept 2011

Lupski James R, Belmont John W, Boerwinkle Eric, Gibbs Richard A

Abstract excerpt

Human diseases are caused by alleles that encompass the full range of variant types, from single-nucleotide changes to copy-number variants, and these variations span a broad frequency spectrum, from the very rare to the common. The picture emerging from analysis of whole-genome sequences, the 1000 Genomes Project pilot studies, and targeted genomic sequencing derived from very large sample sizes reveals an...

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Identifiers

PMID: 21962505
DOI: 10.1016/j.cell.2011.09.008
PMCID: PMC3656718

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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