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Article

Biomarker-based treatment selection in early-stage rectal cancer to promote organ preservation.

The British journal of surgery - 1 Sept 2014

Leong K J, Beggs A, James J, Morton D G, Matthews G M, Bach S P

Abstract excerpt

BACKGROUND: Total mesorectal excision (TME) remains commonplace for T1-2 rectal cancer owing to fear of undertreating a small proportion of patients with node-positive disease. Molecular stratification may predict cancer progression. It could be used to select patients for organ-preserving surgery if specific biomarkers were validated. METHODS: Gene methylation was quantified using bisulphite pyrosequencing in...

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Identifiers

PMID: 25052224
DOI: 10.1002/bjs.9571
PMCID: PMC4282074

Genes

RARB
CHFR
CXCL12
DAPK1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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