Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

WWOX modulates the gene expression profile in the T98G glioblastoma cell line rendering its phenotype less malignant.

Oncology reports - 1 Oct 2014

Kośla Katarzyna, Nowakowska Magdalena, Pospiech Karolina, Bednarek Andrzej K

Abstract excerpt

The aim of the present study was to assess the influence of WWOX gene upregulation on the transcriptome and phenotype of the T98G glioblastoma cell line. The cells with high WWOX expression demonstrated a significantly different transcription profile for approximately 3,000 genes. The main cellular pathways affected were Wnt, TGFβ, Notch and Hedgehog. Moreover, the WWOX-transfected cells proliferated at less than...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion
Share to Glioblastoma
Share to Hedgehog Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oxidoreductases

Share to Receptors, Notch

Share to Transforming Growth Factor beta

Share to Wnt Signaling Pathway

Share to WW Domain-Containing Oxidoreductase

Source

Open in PubMed Open full text

Identifiers

PMID: 25051421
DOI: 10.3892/or.2014.3335
PMCID: PMC4148378

Genes

WWOX

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

WWOX modulates the gene expression profile in the T98G glioblastoma cell line rendering its phenotype less malignant.PMID 25051421Read ↗

The WWOX Gene Influences Cellular Pathways in the Neuronal Differentiation of Human Neural Progenitor CellsSemantic proximity Read ↗

PLEK2, RRM2, GCSH: A Novel WWOX-Dependent Biomarker Triad of Glioblastoma at the Crossroads of Cytoskeleton Reorganization and Metabolism AlterationsSemantic proximity Read ↗

Molecular analysis of WWOX expression correlation with proliferation and apoptosis in glioblastoma multiformeSemantic proximity Read ↗

Role of WW domain proteins WWOX in development, prognosis, and treatment response of glioma.Semantic proximity Read ↗

Molecular landscapes of glioblastoma cell lines revealed a group of patients that do not benefit from WWOX tumor suppressor expressionSemantic proximity Read ↗

WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies.Semantic proximity Read ↗

Deletion of the WWOX gene and frequent loss of its protein expression in human osteosarcomaSemantic proximity Read ↗

Different Approaches for the Profiling of Cancer Pathway-Related Genes in Glioblastoma CellsSemantic proximity Read ↗

The WWOX gene in brain development and pathologySemantic proximity Read ↗

Epigenetic Activation of WNT5A Drives Glioblastoma Stem Cell Differentiation and Invasive GrowthSemantic proximity Read ↗

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer CellsSemantic proximity Read ↗

ZFX regulates glioma cell proliferation and survival in vitro and in vivoSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.