Article
Reduced cerebral gray matter and altered white matter in boys with Duchenne muscular dystrophy.
Annals of neurology - 1 Sept 2014
Doorenweerd Nathalie, Straathof Chiara S, Dumas Eve M, Spitali Pietro, Ginjaar Ieke B, Wokke Beatrijs H, Schrans Debby G, van den Bergen Janneke C, van Zwet Erik W, Webb Andrew, van Buchem Mark A, Verschuuren Jan J, Hendriksen Jos G, Niks Erik H, Kan Hermien E
Abstract excerpt
OBJECTIVE: Duchenne muscular dystrophy (DMD) is characterized by progressive muscle weakness caused by DMD gene mutations leading to absence of the full-length dystrophin protein in muscle. Multiple dystrophin isoforms are expressed in brain, but little is known about their function. DMD is associated with specific learning and behavioral disabilities that are more prominent in patients with mutations in the...
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