Article
The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer.
The Journal of infectious diseases - 15 Dec 2014
Boisen Nadia, Hansen Anne-Marie, Melton-Celsa Angela R, Zangari Tonia, Mortensen Ninell Pollas, Kaper James B, O'Brien Alison D, Nataro James P
Abstract excerpt
BACKGROUND: A Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli (EAEC) strain of serotype O104:H4 caused a large outbreak in 2011 in northern Europe. Pathogenic mechanisms for this strain are unclear. We hypothesized that EAEC genes encoded on the pAA virulence plasmid promoted the translocation of Stx2a across the intestinal mucosa. METHODS: We investigated the potential contribution of...
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